LNA phosphoramidite
Advantages and disadvantages of LNA
Provided lineup (excerpt) The catalog includes the main LNA amidites: LNA-A(Bz) amidite (CAS: 206055-79-0) LNA-G(dmf) amidite (CAS: 709641-79-2) LNA-T amidite (CAS: 206055-75-6) LNA-C(Bz) amidite (CAS: 206055-82-5) Characteristics of LNA phosphoramidites The most notable feature of LNA is that the 2'-O and 4'-C of the ribose ring are linked (locked) by a methylene bridge. The advantages brought by this structure are remarkable. 1. Advantages of LNA ■ Improved thermal stability (increased T_m value) ■ Enhanced nuclease resistance ■ Excellent mismatch discrimination ability 2. Disadvantages to be aware of and "smart" usage ■ Off-target effects and toxicity risks ■ Lack of flexibility
- Company：サパラ
- Price：Other
